Ext JS is a cross-browser JavaScript library for building rich internet applications.
I ran into this a while back doing a project (thx Paul and Nick for pointing this out), and have been keeping an eye out on their latest developments. Version 2.1 now available for download [2] allow you to enrich your web application in ways you can only dream of. You don't believe me, check it out for yourself here [3].
Links:
[1] http://linux.philosweb.com/drupal/category/it/software/development
[2] http://extjs.com/products/extjs/download.php?dl=extjs21
[3] http://extjs.com/deploy/dev/examples/samples.html